Brad Feld

Tag: larry gold

I had a wonderful time interviewing Larry Gold last night at Entrepreneurs Unplugged. Larry is a special guy and someone I learn from every time I’m with him. Among the many great stories he told, including a doozy about the time he was a sophomore at Yale, he had a powerful one about how entrepreneurs assess potential outcomes. It resulted in a fun version of entrepreneurial math.

Envision a scenario where you there are 10 separate things you need to do to have a successful outcome. Each one has a 90% probability of success. What’s the probability that you will achieve a successful outcome?

I struggled with 6.041: Probabilistic Systems Analysis and Applied Probability (the probability course I took as an undergraduate) – it was one of those courses where I felt like I was a week behind for the entire semester. I did better in 15.075: Statistical Thinking and Data Analysis – maybe I was a little older, it was a little easier than 6.041, or I was more interested because I liked the professor better. If you are having trouble with a quick answer, both courses are available to you on MIT OpenCourseWare.

Back to the question. If you guessed around 35% you are correct. It’s actually 34.87%, which is (.9)^10. Now, by using the word separate, I’m implying 10 independent events, but this is the nuanced joy of theory versus practice.

Larry pointed out with glee that regardless, entrepreneurs believe when they start down the path of doing these 10 things there will be a successful outcome. Hence entrepreneurs math is (.9)^10 = 1.

Whether you agree with the math or not, it’s a great anecdote. So many things that we try as entrepreneurs and investors fail. We never make an investment thinking “this isn’t going to work”; we always invest thinking “this will work.” I don’t know any entrepreneurs who started their business thinking “this will fail” or even “this only has a 35% chance of working out.”

This shit is hard. And it’s low probability. Even if you have an ultimately successful outcome, many of the things you are going to try along the way are going to fail. But to do them, you’ve got to believe they are going to work. You’ve got to enter into the illusion that (.9)^10 = 1.


This Entrepreneurs Unplugged with Larry Gold is going to be special. If you don’t know Larry Gold, he’s just amazing.

Larry is one of the originals in the Boulder biotech scene, having founded numerous successful companies including NeXagen (acquired by Gilead) and Synergen (acquired by Amgen). He’s been a professor at CU Boulder since 1980 and was the  chairman of the Molecular, Cellular and Developmental Biology Department from 1988 to 1992. So – when you think of the evolution of the Boulder startup community around life sciences, Larry has been involved since the beginning.

I’ve gotten to know Larry over the past few years through a few different vectors. He and my dad (Stan Feld) have become friends and my dad participates in Larry’s annual GoldLab Symposium. He and I have spent some 1:1 time together and I’m blown away by how similar some of our values and deeply held beliefs are. In Larry, I’ve definitely found a mentor and someone whose path I can learn from as I get older.

Next week on February 18th, I have the honor of having a conversation with him as a part of the Silicon Flatirons Entrepreneurs Unplugged series. He’ll be telling his story, and with the help of the audience, I’ll explore his background that resulted in a successful career. I encourage you to join us.