Backing Up Your Stem Cells
The science fiction of the last 30 years is rapidly becoming reality as technologies such as virtual reality and artificial intelligence are becoming more real and present with each passing day. While my jetpack still seems ponderously far away and cars are becoming self-driving instead of flying, we are making progress.
In medicine, progress is methodical and incremental. As lives are literally at stake, it’s imperative to move forward in a logical and data-driven manner. The resulting regulatory requirement of clinical trials may sometimes be seen as an innovation-stifling burden, but lengthy clinical trials protect patients by ensuring safety and efficacy of therapies. The result? As real advancements are being made in biotechnology, such as engineered cells to fight cancer or using stem cells to regenerate the spine, news and hype eventually quiets during decade long timeline for these technologies to clear trials. There is a bright horizon of therapies that many of us are unaware of.
While I’m not a biotech investor, I ran into a company in Techstars Class 92 (Seattle 2017) called Silene Biotech that fascinated me. The founder, Alex Jiao, has been focused on regenerative medicine for the past decade, an area of research that still feels strongly like science fiction. The idea is to use our cells outside the body to regenerate or regrow lost tissues and organs. A buzzword in this space is “stem cells” and nowadays most people are familiar with the general concept. Stem cells can self-renew and turn into other cells, so their potential is incredible for regenerative medicine.
Currently, there is a lot of mythology and misinformation surrounding stem cells. Unlike newts which can regenerate their limbs, our bodies have limited repair mechanisms and our stem cells can only do so much. However, there are businesses purporting that a simple injection of unmanipulated stem cells can work miracles. The FDA disagrees, and without any compelling data from a clinical trial, most scientists would disagree as well.
I learned from Alex that not all stem cells are the same. Different stem cells have varying abilities to regenerate and turn into other tissues. Furthermore, we are also realizing that it takes guidance and manipulation to coax a stem cell into the correct cell or tissue for regeneration. And new technologies allow us to reprogram adult cells into more “potent” stem cells. These factors have now led to stem cell-based clinical trials to treat diseases such as macular degeneration and heart disease, with some early promising results.
There are still limitations to stem cell technology. One major limitation is that we are realizing age and environment can have a profound effect on stem cell function and even safety. Essentially, the older we are, the older all of our cells (including stem cells) become, and as a result, our bodies’ natural repair mechanisms deteriorate or stop.
Given these factors, I was excited about Alex’s notion that “backing up” our cells and stem cells could be a valuable tool for improving and extending our health in the near future. We can stop the biological aging of our stem cells by putting them in a deep freeze at an earlier age, when they have fewer mutations and damage. Banking our stem cells will then allow us to eventually generate and bank other tissues for self-use, like a population of heart cells for cardiac repair or a population of liver cells to diagnose drug toxicity. As technology moves towards a future where it’s technologically possible to engineer tissues and organs from our own stem cells, backing stem cells up today can give us the best opportunity to use them when we need them.
I love the idea of backing up my stem cells. Alex and his team are coming to Boulder to do this for me on 11/29. If you are interested in backing up your stem cells, Alex has offered to do it for a few others in Boulder when he is here. If you are interested, just email me and I’ll connect you with Alex.